Jan Storek

Professor

MIID, Medicine

MD, PhD, FACP


Contact information

Phone

Office: 403-210-8630

Web presence

PubMed

Storek


Preferred method of communication

ADMIN ASSISTANT

Cindy Miskolczi-McCallum

Email: cindy.miskolczi.mccal@ucalgary.ca

Office: 403-210-3935


Research and teaching

Area of Focus

  • Hematopoietic Cell Transplantation

Summary of Research

Hematopoietic cell transplantation is used to treat hematologic malignancies, aplastic anemia and congenital defects of hematopoiesis. The most frequent complications are immune complications. These include either insufficient immunity against microorganisms or leukemic cells, leading to infections or leukemic relapse, or deleterious immunity leading to, e.g., graft-versus-host disease.We study how immunity develops after hematopoietic cell transplantation. This includes evaluation of immunity against virus-infected cells or leukemic cells, with the goal of limiting the incidence of infections and relapse. It also includes evaluation of alloimmunity, autoimmunity and allergy. For example, we search for biomarkers of graft-vs-host disease, with the goal of improving donor selection or treating graft-vs-host disease preemptively.  For another example, we explore whether and how allergic diseases (asthma, rhinitis, eczema) or autoimmune diseases are transferred from a hematopoietic cell donor to a recipient, or cured if a hematopoietic cell transplant recipient with an autoimmune or allergic disease receives the graft from a healthy donor.


Biography

1978-1984  Charles University School of General Medicine, Prague, Czech Republic,MUDr (MD equivalent, 1984) and CSc (PhD equivalent, 1994)1984-1994  Research and Clinical Trainee (Internal Medicine, Hematology, Medical Oncology, Hematopoietic Cell Transplantation, Immunology), Charles University Hospital, Prague, University of California, Los Angeles, University of Washington, Seattle, and Fred Hutchinson Cancer Research Center, Seattle1994-2004   Staff, Fred Hutchinson Cancer Research Center and University of Washington, Seattle2004-Present   Associate and Full Professor, Departments of Medicine (Hematology), Oncology and Microbiology/Immunology/Infectious Diseases, University of Calgary, and Alberta Blood and Marrow Transplant Program, Alberta Health Services Research