Research and teaching
- Protein Phosphatase
- Cell Signaling
Summary of Research
The type one protein phosphatases (PP1) bind a majority of their regulatory subunits through a short motif designated RVxF. In humans several hundred PP1 binding proteins have been identified and several hundred more await discovery. Through affinity approaches and mass spectrometry we have identified many of these human PP1 complexes and have been characterizing several PP1 binding partner interactions using a variety of approaches. Currently we are focusing on PP1 partners linked to cell cycle control and cancer. Of particular interest is the control of PP1 function by phosphorylation of the partner PP1 binding partners.
Dr Moorhead completed his PhD at Queeen’s University followed by postdoctoral research in Dundee with Sir Philip Cohen and Carol MacKintosh where he developed his interest in protein phosphatases. He joined the University of Calgary in 1998 and continues to work on protein phosphatases and their role in cell signaling.