Nicolas Jacquelot
Assistant Professor
PhD
Contact information
Research and teaching
Area of Focus
- Cancer Immunology
- Immunotherapy
- Innate Immunity
Summary of Research
Our laboratory is studying the role and function of the immune system in cancer. We examine the contribution of the innate lymphoid cells (ILCs) to tumor development and therapy responses. Despite their critical role in fighting infections and promoting inflammation driving autoimmune diseases, how ILCs, considered as the innate counterpart of adaptive lymphocytes, impact tumor development, progression and cancer treatments remain vastly unknown. We leverage our expertise in mouse models, tissue biology, tumor immunology, flow-cytometry, microscopy, and multi-omics analyses to perform experiments that test the role and function of ILCs in cancer. Ongoing research efforts include (i) investigating the cellular and molecular pathways influencing ILC function in tumors, (ii) dissecting ILC signaling pathways and communication with other cells within the tumor microenvironment, and (iii) determining ILC prognostic values and therapeutic potential in cancer. Our overreaching goal is to improve cancer patient prognosis through the development of ILC-based treatments.
Biography
Dr. Nicolas Jacquelot completed his PhD in Cancer Immunology in the laboratory of Professor Laurence Zitvogel at Gustave Roussy Institute. His work has shed light on new molecular and cellular pathways that critically influence patient prognosis and immunotherapy outcomes. He pursued his postdoctoral training in Professor Gabrielle Belz’s group at The Walter and Eliza Hall Institute of Medical Research and in Professor Pamela Ohashi’s laboratory at the Princess Margaret Cancer Centre. His research has revealed the role and function of innate lymphoid cells in anti-tumor immunity and immunotherapy responses. In January 2023, he opened his own laboratory at the University of Calgary in the Cumming School of Medicine.
