Research Projects

Riddell Centre investigators are advancing cancer treatment by developing innovative cell and immune therapies. Learn more about the cutting-edge methods and research projects driving these breakthroughs forward.

Project	Cancer type(s)	Research Priority	Keywords
Identifying New Targets for Hard-to-Treat Cancers Principal Investigator: Sorana Morrissy Co-Investigators: Theodore Verhey, Jennifer Chan, Michael Monument, David Schriemer	Glioblastoma; Sarcoma	Discovery & Innovation	Data science, proteomics, single cell profiling
Enhancing CAR T-Cell Therapy for Solid Tumours with Engineered Oncolytic Viruses Principal Investigator: Douglas Mahoney Co-Investigators: Franz Zemp, Michael Monument, Jennifer Chan	Sarcoma; Glioblastoma; Solid Cancers	Discovery & Innovation	Oncolytic rhabdoviruses, immune-boosting signals, viral vaccine
Exploring How Gut Bacteria Impact the Effectiveness of CAR T-Cell Cancer Therapy Principal Investigator: Kathy McCoy Co-Investigators: Robert Puckrin, Sorana Morrissy, Douglas Mahoney, Mona Shafey	Blood cancers	Discovery & Innovation	Preclinical models, microbiome, microbial therapy
Precision CAR T-Cell Therapy for Glioblastoma: Developing Safe, Multi-Targeted Treatments with Logic-Gated CAR T-Cells Principal Investigator: Franz Zemp Co-Investigators: Sorana Morrissy, Douglas Mahoney, Jennifer Chan	Glioblastoma	Discovery & Innovation	Target marker variability, adaptive therapies, immune cell engineering
Advancing CAR T-Cell Therapy: Overcoming Challenges in Glioblastoma with a Hematopoietic Stem Cell-Derived Approach Principal Investigator: Douglas Mahoney Co-Investigators: Jennifer Chan	Glioblastoma; Cancer agnostic	Discovery & Innovation	Genetic engineering, controlled CAR expression, delivery systems
Improving CAR T-Cell Therapy with Gene-Editing Technologies Principal Investigator: Pierre Billon Co-Investigators: Douglas Mahoney, Franz Zemp	Cancer agnostic	Discovery & Innovation; Biomanufacturing	CAR T cell therapy, CRISPR gene editing, preclinical models
Developing a Novel CAR Macrophage Therapy to Treat Glioblastoma Principal Investigator: Jennifer Chan Co-Investigators: Douglas Mahoney, Johnathan Canton	Glioblastoma	Discovery & Innovation	Immune cell engineering, tumour microenvironment, cell signaling
Unlocking the Power of Dendritic Cells to Strengthen Cancer Immunity Principal Investigator: Johnathan Canton	Cancer agnostic	Discovery & Innovation	Antigen cross-presentation, CAR XP, immune cell activation
The IMPACT Study: Understanding and Overcoming CAR T Manufacturing Failures Principal Investigator: Kevin Hay Co-Investigators: Robert Holt	Blood cancers	Discovery & Innovation; Biomanufacturing	CAR T-cell manufacturing, therapy accessibility, cell therapy pipeline
BCAR1: Advancing Armored CAR T-Cell Therapy for Multiple Myeloma Principal Investigator: Nizar Bahlis Co-Investigators: Paola Neri, Douglas Mahoney	Blood cancers	Clinical Research & Translation	Single-cell DNA sequencing, BCMA-targeting therapy, clinical translation
CLIC-2201: Advancing a Made-in-Canada CAR T Therapy into Clinical Trial Principal Investigator: Kevin Hay Co-Investigators: Victor Lewis, Robert Puckrin, Natasha Kekre, Hannah Cherniawsky, Amanda Li, Harold Atkins, John Kuruvilla, Joerg Krueger	Blood cancers	Clinical Research & Translation	Clinical trial development, leukapheresis, biomarker analysis