Preferred method of communication
Research and teaching
Area of Focus
- Genome instability as a consequence of replication of fragile DNA sites
Summary of Research
Genomic instability is a hallmark of cancer. Genomic rearrangements are thought to be the means by which cells develop aberrant characteristics that drive their conversion into cancer cells. A central thrust of our laboratory is to characterize early events that lead to chromosomal instability and tumorigenesis.
Our research focuses on genomic instability that arises during DNA replication and double strand break (DSB) repair. Replication forks can collapse and cause DNA damage if mishaps are encountered when duplicating in the genome. We aim to understand how the architecture of the fork is preserved during stress and to characterize the factors that tether broken ends of DNA together at DSBs, preventing them.
Dr. Cobb is a Professor in the Departments of Biochemistry & Molecular Biology and Oncology and the co-Lead for Research at the Arnie Charbonneau Cancer Institute. She obtained her PhD from University of Tennessee in 2000 and trained at the University of Geneva, Switzerland until the end 2006. In 2007, she opened her own laboratory at the University of Calgary’s Cumming School of Medicine.