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Medical Graduate Education (MDGE) 621-632 Module series

Submitted by srtariqu on Sun, 01/31/2016 - 6:05pm

Medical Science (MDSC) 683

Medical Science (MDSC) 683 is the core Cancer Biology graduate course at the Cumming School of Medicine. This is a modular course, with each module encompassing a total of eight lectures (twice a week) focussing on a specific topic.

FALL SEMESTER MODULES

WINTER SEMESTER MODULES

Submitted by srtariqu on Sun, 01/31/2016 - 6:07pm

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Tues | Thur
10:00 - 11:20 AM

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Module A1: Anti-tumor Drug Discovery and Current Cancer Therapies

Sept-Oct

Class Limit: 12

AVAILABLE 2016-2017

A1: Anti-tumor Drug Discovery and Current Cancer Therapies

Dr. Aru Narendran

Dates and Room Location:

Sept 13 - B22, Sept 15 - G644 ** start time 10:30-11:50am, Sept 20 - G643,
Sept 22 - G744 *start time 10:30-11:50am, Sept 27 - B22, Sept 29 - O'Brien 1504, 
Oct 4 - B22, Oct 6 - B22

Objectives and Focus

This module consists of understanding the effective use of molecular pathology to identify biomarkers and potential targets for modulation. We explore the concepts of targeting stem cells, identification of small molecular weight inhibitors (drug discovery) and the formulation of clinical trials. Major emphasis will be placed on formulating an effective hypothesis and to design preclinical studies that will include cutting-edge ideas on molecular cancer therapeutics. Objectives include: (i) To understand the role of targeted therapeutics in refractory malignancies, (ii) To identify key concepts of effective preclinical studies in oncology and their contribution to early phase clinical trials, (iii) To learn about the key concepts in new agent discovery programs, (iv) To learn about some of the potential experimental avenues for the identification of effective novel therapeutics for pediatric malignancies

 

Assessment %Grade
Reveiw Article  40%
Writing  20%
Oral Presentation  25%
Participation   15%
 100%

          

Module A2: Proteomics & Metabolomics and Cancer Biomarker Discovery

Oct-Nov

Class Limit: 6

AVAILABLE 2016-2017

A2: Proteomics & Metabolomics and Cancer Biomarker Discovery

Dr. David Schriemer

Dates and Room Location:

Oct 11, 13, 18, 20, 25, 27 - B22
Nov 1 - G384, Nov 3 - B22

Objectives and Focus

The module will cover proteomics and metabolomics. We will focus on the objectives of these disciplines, the technologies, methods and informatics used in biological mass spectrometry as applied to the ‘omics. As much as possible, examples will be drawn from cancer-related disciplines (research or clinical). Assessment will involve the analysis of a protein sample provided to (or by) the student. It will require lab-work in the SAMS Centre for Proteomics, and the generation of an informatics report. Each student will be expected to keep up with assigned readings, and select a paper from the recent literature in either proteomics or metabolomics, for presentation in journal-club style.

 

Assessment %Grade
   
Lab Assignment 60%
Oral Presentation 30%
Participation  10%
  100%

Module A3: Anti-tumor Virotherapy and Tumor Immunology

Nov-Dec

Class Limit: 7

AVAILABLE 2016-2017

A3: Tumour Immunology and Immunotherapy

Dr. Douglas Mahoney

Dates and Room Location:

Nov 15 (G743), Nov 17 (G743), Nov 22 (G746), Nov 24 (G743), Nov 29 (G743) 
Dec 1 (G743), Dec 6 (G743), Dec 8 (G743)

Objectives and Focus

This is a lecture/presentation-based module that will cover introductory topics in tumor immunobiology and immunotherapy. Fundamental and translational topics will be addressed, including: tumour immunogenicity, tumour immune surveillance and editing, immune escape, active immunotherapy, passive immunotherapy, virotherapy and viral vaccines, therapies targeting immunosuppressive mechanisms, and personalized immunotherapy. A basic understanding of tumour biology and immunology is advantageous but not a prerequisite. Classes will consist of an introductory lecture on the topic, followed by a student presentation (mock PDF presentation) and questions. Other evaluation components include a mock PDF fellowship application, class participation and a short final exam.

 

Assessment %Grade
Oral Presentation  30%
Mock Fellowship Applic'n  30%
Written Exam  20%
Participation  20%
   100%

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Mon | Wed
10:00 - 11:20 AM

Submitted by srtariqu on Sun, 01/31/2016 - 5:20pm

Module M1: Ethics of Clinical Trials and Scientific Data Analysis

Oct - Nov

Class Limit: 6

AVAILABLE 2016-2017

M1: Ethics of Clinical Trials and Scientific Data Analysis

Dr. Aru Narendran
Dr. Aaron Goodarzi
Dr. Marco Gallo
Dr. Jennifer Chan

Dates and Room Location:

Oct 12, Oct 17, Oct 19, Oct 24 (G743), Oct 26 (1464B), Oct 31 (G636) 
Nov 2 (G743), Nov 7 (G743)

Objectives and Focus

This module discusses ethics surrounding scientific research. Students will learn how ethics approval for experiments involving human subjects, human tissues or cells and animal models may be obtained successfully. Students will also learn about the ethical issues surrounding the storage, management and analysis of genomic data, and the use of genomic data to inform clinical decisions. Students will hear about what constitutes unethical data manipulation, modern methods of detecting falsified data used by journals, rules surrounding authorship and what is ethical (and not) with regards to data analysis of immunoblots, immunofluorescence experiments and many other typical assays used in cancer research. For assessment, students will complete a mock ethics application, be assessed for participation in class discussion and write three short quizzes. 

Assessment %Grade
Clinical Trial Proposal 30%
Essay 30%
Mock Peer Review 30%
Participation 10%
  100%

Module M2: Principles and Applications of Advanced Light Microscopy

Nov-Dec

Class Limit: 6

AVAILABLE 2016-2017

M2: Principles and Applications of Advanced Light Microscopy

Dr. Pina Colarusso
Dr. Grant Gordon

Dates and Room Location:

Nov 21, 23, 25, 28, 30
Dec 2, 5, 7, 12

Objectives and Focus

The Light Microscopy Module is targeted to students who have little formal training in optical microscopy. The module will introduce the fundamentals of standard wide-field fluorescence microscopy as well as confocal and multiphoton techniques. Key concepts such as the optical light path, spatial resolution, and sampling will be emphasized. In addition, students will have the opportunity to assemble basic bright-field and fluorescence microscopes using optical “lego.” The module blends lectures, small group discussions, and hands-on activities; a high degree of participation will be expected. The assessment will be based on participation, assignments, lab reports and a final exam.

NOTE: Due to the need for practical training in a laboratory setting, this module is LONGER than the others, with 9 x 130 min lectures.

 

Assessment %Grade
Lab Reports 30%
Assignments 30%
Written Exam 30%
Participation 10%
  100%

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Tues | Thur | Fri
9:00 - 10:20 AM

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Module N: Introduction to Neural Development

Sept-Oct

Class Limit: 6

AVAILABLE 2016-2017

N: Neural Development

Dr. MN Nguyen
Dr. C Schuurmans,
Dr. S McFarlane,
Dr. D Kurrasch

Dates and Room Location: TBD

Objectives and Focus

The Neural Development module will cover fundamental principles of central nervous system development. The module encompasses the first third of MDSC 619.01, which is a core course for all Neuroscience graduate students. The first third of MDSC619.01 can be taken as a stand-alone module. It will cover basic principles of neural induction and neurogenesis, regionalization of the neural tube, neuronal migration, circuit formation (axons and dendrites), neurodevelopmental disorders, and model organisms. Students will be evaluated in a final exam and in two assignments. The first assignment will be to write a News and Views article on a recent publication in neural development, and the second will be a Presentation of new animal models for neurological diseases.

 

Assessment %Grade
News and Views 20%
Presentation 20%
Written Exam 60%
   
  100%

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Tues | Thur
10:00 - 11:20 AM

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Module B1: Cell Cycle Regulation in Cancer and Aging

Jan-Feb

Class Limit: 12

AVAILABLE 2016-2017

B1: Cell Cycle Regulation in Cancer and Aging

Dr. Karl Riabowol

Dates and Room Location:

Jan 10 (G744), Jan 12 (G500), Jab 17 (G744), Jan 19 (O1506), Jan 24 (G744), Jan 26 (G744), Jan 31 (G744)
Feb 2 (G744), Feb 7 (G744)

Objectives and Focus

The module will cover cancer and aging. We will overview the links between cancer & aging, the experimental definition of the cell cycle, major events in G0, G1, S, G2, M, drivers and regulators of the cell cycle including oncogenes & tumor suppressors, cyclins, CDKs, CDIs & links to the cell cycle through tumour suppressors. An overview of biological and replicative aging will include human biological lifespan potential, changes in life expectancy and rectangularization of the survival curve, experimental models used in aging research, forms of aging in mammals and the "Hayflick model" of replicative senescence including recent developments regarding the role of epigenetic modifications in cancer & aging. Students will need to keep up with assigned readings and select a recent paper in the areas of biological aging and/or cancer for presentation to the class, and will be responsible for preparing critiques of the presentations by class mates.

 

Assessment %Grade
Critiques of Presentations 30%
Oral Presentation #1 25%
Oral Presentation #2 25%
Discussion of Papers 20%
  100%

Module B2: Epigenetics and Chromatin Dynamics

Feb-Mar

Class Limit: 12

AVAILABLE 2015-2016

B2: Epigenetics and Chromatin Dynamics

Dr. Jennifer Cobb
Dr. Aaron Goodarzi

COURSE NOT AVAILABLE THIS TERM

Objectives and Focus

This modules covers the fundamentals of eukaryotic chromatin assembly, dynamic chromatin regulation (during differentiation, cell cycle progression and the DNA damage response) and post-translational modifications that comprise the field of epigenetics. We will cover the concepts of DNA methylation, histone acetylation, histone methylation, histone phosphorylation (and other histone PTMs), histone variants, regulatory siRNA, nucleosome remodelling and higher-order chromatin organization. Cancer and disease-associated epigenetic alterations will be discussed in detail. Experimental methodologies for epigenetics, both historical and modern, will be reviewed in detail via publication-focused presentations by lecturers and students. Students will be assessed on the basis of two short quizzes, their oral presentation, an exam and their participation in the discussion during class.

 

Assessment %Grade
Quizzes (2) 20%
Oral Presentation 30%
Written Exam 40%
Participation 10%
  100%

Module B3: DNA Damage Signalling & Repair

Mar-Apr

Class Limit: 12

AVAILABLE 2016-2017

B3: DNA Damage Signalling & Repair

Dr. Susan Lees-Miller,
Dr. J. Cobb
Dr. Tara Beattie

COURSE NOT AVAILABLE THIS TERM

Objectives and Focus

This module focuses on the major DNA repair pathways in eukaryotic cells, highlighting proteins involved in the cellular responses to ionizing radiation. We will cover the main DNA repair pathways including base excision repair, mismatch repair, nucleotide excision repair, and DNA single strand and double strand break repair. We will stress the mechanisms of non-homologous end joining and homologous recombination repair. As well the topics of ATM and ATR dependent signaling, H2AX foci and roles of protein phosphorylation and protein ubiquitination, the Faconi Anemia pathway, and the relationship of replication stress and telomere maintenance to the DNA damage response will be covered.

 

Assessment %Grade
   
Oral Presentation 20%
Written Exam 30%
Written Assignment 50%
  100%

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Mon | Wed
10:00 - 11:20 AM

Submitted by srtariqu on Sun, 01/31/2016 - 6:00pm

Module C1: Cancer Cell Biology - Fundamentals and Current Topics

Jan-Feb

Class Limit: 12

AVAILABLE 2016-2017

C1: Cancer Cell Biology - Fundamentals and Current Topics

Dr. Shirin Bonni
Dr. Donna Senger

Dates and Room Locations:

Jan 9, 11, 16 (G744), Jan 18 (O'Brien 1508), Jan 23 (G744), Jan 25 (G744), Jan *27 (G744)
Feb 1 - (G638)

Objectives and Focus

This is an advanced, discussion-based module featuring an analysis of the current literature in cell biology with an emphasis on developmental systems. Background in cell biology and signal transduction is essential. Topics in the general area of cell biology will be selected for each of the students based on their own research projects such that it enhances their learning experience. Topics covered include: 1./ Cancer stem cells, 2./ Cell polarity, 3./ Cell migration, 4./ endocytosis 5./ mitochondrial biogenesis to name a few areas that have been covered in the past.

 

Assessment %Grade
   
Oral Presentation 50%
News/Views Article 25%
Participation 25%
  100%

Module C2: Cancer Cell Invasion, Metastasis and Angiogenesis

Feb-Mar

Class Limit: 12

AVAILABLE 2016-2017

C2: Cancer Cell Invasion, Metastasis and Angiogenesis

Dr. Paul Beaudry

Dates and Room Location:

NOT AVAILABLE THIS SEMESTER

Objectives and Focus

Our evolving understanding of the interaction of the cancer cell with the host stroma will be the focus of this module. Angiogenesis, cell invasion and metastasis will be discussed from molecular, cell biological and clinical perspectives. Methods of experimental modelling of metastatic behavior and angiogenesis, as well as their respective advantages and limitations will be discussed. There will be lab demonstration of available in vitro and in vivo invasion/metastasis/angiogenesis models. Students will be evaluated on the basis of their literature review and presentation on a topic within this area, a focused research proposal, and class participation.

 

Assessment %Grade
   
Oral Presentation 40%
Research Proposal 40%
Participation 20%
  100%

Module C3: Intracellular Cancer Signalling Transduction Pathways

Mar-Apr

Class Limit: 12

AVAILABLE 2016-2017

C3: Intracellular Cancer Signalling Transduction Pathways

Dr. Morley Hollenburg
Dr. Shirin Bonni

Dates and Room Locations: All classes will be in G744

Mar 13, Mar 15, Mar 20, 22, 27, Mar 29 
Apr 3, Apr 5

Objectives and Focus

This module will cover fundamental principles and regulation of receptor-mediated and intracellular-mediated signaling pathways that have important implications in cancer biology. Lectures will be given covering various topics in signaling including a general introduction on receptor and intracellular signaling mechanisms with focus on receptor tyrosine kinase (RTK) and serine/threonine kinase receptor signaling, regulation and function of the intracellular tyrosine kinase Src and its downstream signaling, and role of phosphatase in signaling. Students will also be presenting journal club presentations on assigned papers in areas that complement the lecture materials where other concepts or pathways in signaling are covered.

 

Assessment %Grade
Critique of Paper 35%
Oral Presentation 35%
Written Exam 20%
Participation 10%
  100%